Within tissues are cells that are controlled by and interact with Type I collagen. Many of these connective tissue cells are “attachment activated“. This means that the cells seek out attachment points on the Type I collagen, become attached, and activate the cascade of events leading to bone formation. How the bone graft material responds to these cells is referred to as the mechanism of action. The core elements of this response are:

  • Providing a scaffold for local cells (osteoconduction)
  • Providing instructions to local cells (osteoinduction)
  • Introducing donor cells (osteogenesis)


i-FACTOR™ Bone Graft: Mechanism of Action

i-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone.

i-FACTOR Bone Graft facilitates and expedites the ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue.

The high affinity between cells and P-15 supports the physiological mechanism of action in which cells bind to the P-15 and “turn on” to perform their genetically programmed job of making bone.

The novel i-FACTOR Bone Graft “Attract, Attach, Activate” mechanism of action enhances the body’s natural bone healing process.