i-FACTOR Biologic Bone Graft

  • How It Works

    How It Works

    Within tissues are cells that are controlled by and interact with Type I collagen. Many of these connective tissue cells are “attachment activated“. This means that the cells seek out attachment points on the Type I collagen, become attached, and activate the cascade of events leading to bone formation. How the bone graft material responds […]

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  • What Makes It Works

    What Makes It Works

    The way a bone grafting technology works depends on many factors including the properties of the graft itself. Whether natural (allograft, simple demineralized bone matrix) or synthetic (hydroxyapatite, calcium phosphate), structure is key to an osteoconductive scaffold providing a suitable workplace for bone forming cells. Resorption time, porosity, and mechanical strength can vary widely in […]

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  • Proof It Works

    Proof It Works

    Evidence comes in many forms – with personal experience being the most credible. But before personal experience can be gathered, most bone graft materials must be evaluated under the regulation of the FDA. Tissue products (cellular bone matrices and simple allografts) are not required to provide any clinical proof of safety or performance to the FDA. Evidence […]

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  • Animation

    Animation

      i-FACTOR Bone Graft is the only biologic bone graft made of a synthetic small peptide (P-15) bound to an anorganic bone mineral (ABM). This unique combination creates a surface-bound “Attract, Attach, Activate” mechanism of action that enhances the body’s natural bone healing process. Being surface-bound, all cellular activity resulting from P-15 attachment is restricted […]

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  • Clinical Evidence

    i-FACTOR Peptide Enhanced Bone Graft exhibits superior clinical outcomes compared to autograft (the ‘gold standard’) in anterior cervical discectomy and fusion. Arnold PM, et al. Efficacy of i-FACTOR Bone Graft versus autograft in anterior cervical discectomy and fusion. Results of the prospective, randomized, single-blinded Food and Drug Administration Investigational Device Exemption study, Spine (Phila Pa, 1976), […]

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  • Pre-Clinical Evidence

    The synthetic P-15 peptide results in early bone formation and fusion in a pre-clinical spine model. Sherman PB, et al. Evaluation of ABM/P-15 versus autogenous bone in an ovine lumbar interbody fusion model, Eur Spine J, 2010; 19(12):165-63 The synthetic P-15 peptide results in greater tissue volume fraction and thicker trabeculae compared to autograft in the […]

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  • Mechanism of Action

    Synthetic P-15 peptide is bound to the anorganic bone mineral and ensures bone grows where you want it. Hole BB, et al. A study of biologically active peptide sequences (P-15) on the surface of an ABM scaffold (PepGen P-15) using AFM and FTIR, J Biomed Mater Res A, 2005;74(4):712-21 Qian JJ and Bhatnagar, RS. Enhanced cell attachment […]

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